BIA-System (Blastocyst Implantation Assistance) is the newer lab technique of fermented hatching applied at MAMA Clinic, which implies that the membrane shell surrounding the embryo is removed due to ferment impact before the embryo is implanted. It is often recommended to the couples who have already had previous failed IVF attempts.
During initial stages of development, the human embryo is contained in a layer of proteins, a membrane shell, also known as zona pellicuda. This shell protects the fragile embryo from mechanical damage and also regulates the process of standard conception and provides for the selective delivery of outer environment essences to the organism. In order to successfully implant into the uterine lining, the embryo needs to hatch out of this shell first and then attach to the uterus wall. In normal course, the unaided hatching, or breaking through the shell, takes place on the 5th to 7th day of development, once the embryo has reached the blastocyst stage. The natural hatching is performed via ferments produced by the cells of the embryo. Normally, the embryo is capable of going through this process unaided.
Yet, in some cases, due to abnormal morphology or other irregularities in the membrane, the process of natural hatching is hindered and the conception does not take place. Having observed such complications in many couples with multiple failed IFV attempts, the scientists have developed several artificial hatching methods. The latest and least damaging to the embryo, and thus more perspective for the fertility treatment results, is the fermented hatching.
The fermented hatching applied at MAMA Clinic is called the BIA-System. The essence of this method is similar to the natural process, where the hatching is also carried out by fermented alteration rather than physical impact, as it would be in laser or mechanical hatching. BIA-System is the advanced option, which guarantees a safer and more efficient result.