Маленькие ЭКО-дети растут быстрее

Многих педиатров заботит проблема низкого веса при рождении у детей после ЭКО/ИКСИ. Однако, основываясь на исследовании, опубликованном в августе 2009 года в журнале «Репродукция человека» (Human Reproduction), беспокоиться по этому поводу не стоит.

Советуем почитать: Эко-дети — самые желанные дети на свете

Исследование детей, родившихся после биопсии эмбриона

Как криоконсервация эмбрионов влияет на развитие детей

Исследование развития детей в возрасте от 8 до 18 лет, родившихся после лечение методом ЭКО.

Ученые провели исследование, в котором сравнивали 233 детей, родившихся после ЭКО и 233 детей, родившихся после самостоятельного зачатия.

В ходе исследования обнаружили, что вес детей в трехмесячном и 6-месячном возрасте, родившихся после ЭКО, значительно ниже показателей веса, роста и ИМТ (индекс массы тела) у детей в контрольной группе. Однако, ЭКО дети лучше набирали вес, быстрее росли и продемонстрировали большую прибавку в весе в период позднего младенчества (от 3 месяцев до 1 года) по сравнению с контрольной группой.

Статья опубликована 1августа 2009 в журнале «Репродукция человека» (Human Reproduction)

Growth during infancy and early childhood in relation to blood pressure and body fat measures at age 8–18 years of IVF children and spontaneously conceived controls born to subfertile parents

Manon Ceelen1, Mirjam M. van Weissenbruch1,6, Janneke Prein1, Judith J. Smit1, Jan P.W. Vermeiden2, Marieke Spreeuwenberg3, Flora E. van Leeuwen4 and Henriette A. Delemarre-van de Waal5

1 Department of Paediatrics, Institute for Clinical and Experimental Neuroscience, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands 2 Department of Obstetrics and Gynaecology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands 3 EMGO institute, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands 4 Department of Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands 5 Department of Pediatrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands

Hum. Reprod. Advance Access originally published online on August 1, 2009 Human Reproduction 2009 24(11):2788-2795; doi:10.1093/humrep/dep2736 correspondence address.

BACKGROUND: Little is known about post-natal growth in IVF offspring and the effects of rates of early post-natal growth on blood pressure and body fat composition during childhood and adolescence.

METHODS: The follow-up study comprised 233 IVF children aged 8–18 years and 233 spontaneously conceived controls born to subfertile parents. Growth data from birth to 4 years of age, available for 392 children (n = 193 IVF, n = 199 control), were used to study early post-natal growth. Furthermore, early post-natal growth velocity (weight gain) was related to blood pressure and skinfold measurements at follow-up.

RESULTS: We found significantly lower weight, height and BMI standard deviation scores (SDSs) at 3 months, and weight SDS at 6 months of age in IVF children compared with controls. Likewise, IVF children demonstrated a greater gain in weight SDS (P < 0.001), height SDS (P = 0.013) and BMI SDS (P = 0.029) during late infancy (3 months to 1 year) versus controls. Weight gain during early childhood (1–3 years) was related to blood pressure in IVF children (P = 0.014 systolic, 0.04 diastolic) but not in controls. Growth during late infancy was not related to skinfold thickness in IVF children, unlike controls (P = 0.002 peripheral sum, 0.003 total sum). Growth during early childhood was related to skinfold thickness in both IVF and controls (P = 0.005 and 0.01 peripheral sum and P = 0.003 and 0.005 total sum, respectively). CONCLUSIONS: Late infancy growth velocity of IVF children was significantly higher compared with controls. Nevertheless, early childhood growth instead of infancy growth seemed to predict cardiovascular risk factors in IVF children. Further research is needed to confirm these findings and to follow-up growth and development of IVF children into adulthood.

Источник: Human Reproduction

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